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LDN - Low Dose Naltrexone
Starting at $25/month

LDN ScienceLDN BlogAutoimmune SupportLogin≡ Menu

Low Dose Naltrexone (LDN) modulates your immune system to suppress chronic inflammation and reduce oxidative stress –leading to improved immune function, reduced pain and fatigue, and enhanced quality of life.


FSA / HSA Eligible

LDN - Low Dose Naltrexone
Starting at $25/month

Get started

LDN - Low Dose Naltrexone

Low Dose Naltrexone (LDN) modulates your immune system to suppress chronic inflammation and reduce oxidative stress –leading to improved immune function, reduced pain and fatigue, and enhanced quality of life.

FSA/HSA Eligible 

Get started

Crohn's Disease

In a 2011 study, LDN reduced Crohn’s disease activity in 88% of patients, while 33% achieved remission after 12 weeks

Rheumatoid Arthritis

RA is most often associated with chronic inflammation, while LDN has been shown to lower chronic inflammation 

Thyroid Dysfunction

LDN has been shown to
alleviate 
some or all of symptoms of hypo- & hyperthyroidism &
 regulate the way the thyroid works

Fibromyalgia

LDN acts on specific pain receptors to reduce their over-sensitivity while stimulating the body to naturally lower inflammation

LDN Use Cases

  • Increases levels of endorphins which have powerful antioxidant, anti-inflammatory, and mood boosting properties

  • Lowers pro-inflammatory factors in the body that drive inflammation, pain, weight gain, and age-related decline in health

  • May reduce inflammation in the brain which is associated with fatigue, mental health disorders, and cognitive decline

  • Blocks receptors on immune cells (TLR-4) that drive uncontrolled immune reactivity associated with autoimmune disease, aging, and age-related disease

Enhancing Healthspan

See the science

LDN has not been approved by the FDA for these uses, but there are multiple studies that have shown these benefits.

  • Low dose optimized for safety and anti-inflammatory effects, supported by over 40 years of evidence treating viral infections and autoimmune disease

  • Dosages below 10mg/day are considered "Low Dose Naltrexone" (LDN)—4.5mg/day is the most common

  • Exhibits broad effects across organ systems and inflammatory-driven conditions, supporting its longevity-enhancing potential

  • Used to treat autoimmune diseases and viral infections since 1985

  • AgelessRx is a proud member of the LDN Research Trust

Background & History

During the first three to five days of taking LDN, you may experience mild to moderate levels of the side effects listed. Side effects typically diminish on their own by day five. To reduce the risk of side effects, the recommended protocol is to start with one capsule (1.5mg) for the first week with a gradual increase to the full 4.5mg dose. If you are on thyroid medication, you may need to monitor your thyroid levels more closely as you start LDN. If you develop symptoms of hyperthyroidism while taking LDN, such as heart racing, increased anxiety, restlessness, or trouble sleeping, please stop LDN and talk to your doctor who prescribes your thyroid medication.

Note:  Please stop taking any dosage of Naltrexone a minimum of 48-hours before any surgical procedure or medical diagnostic requiring sedation, such as surgery or a colonoscopy. If you are not sure if you need to stop Naltrexone, please ask your doctor ordering the test or procedure. Additionally, Naltrexone cannot be taken in conjunction with some painkillers. If you need to stop taking Naltrexone for a surgery, and accompanying pain killers are prescribed, you may resume LDN only 48-hours after you take your last painkiller.

* The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Most Common Side Effects of LDN

  • Vivid dreams 

  • Mild anxiety 

  • Insomnia 

  • Headache

For a full list of possible side effects, click here.

What AgelessRx customers are saying

The testimonials on this page are from real AgelessRx customers sources from Trustpilot.com. Individual results may vary. Testimonials are not a guarantee of future results.

Slowing aging has never been simpler

  • Promotes cellular energy production.

  • Supports DNA health and repair.

  • Required to “turn off” genes that accelerate degenerative aging processes.

  • NAD+ is a required “helper” molecule for proteins that regulate other cellular functions. 

Complete intake

Answer a few questions about your health 
history & goals

Ongoing care

Get access to ongoing prescriber care, 100% online

Get medical review

A certified prescriber will review your history to see if LDN is right for you

Enjoy fast, free shipping

If approved, receive your shipped treatment in 
3-5 days

Get access to cutting edge longevity treatments without leaving the couch

Ready to get started?

Start your free online visit now. 

* Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. See below for important safety information. Benefits outlined on AgelessRx.com are based on 3rd party studies. Medication is offered as a subscription service which you can cancel at any time. Actual product packaging may appear differently than shown. Please allow 3-5 days for processing & shipping following medical approval (if required).

You will be automatically enrolled into our billing/refill program based on your plan.

You can request adjustments to your dosages between refills.

Your prescriber may recommend a different dose during your medical intake process.

You can pause or cancel at any time before your next shipment.

Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. See below for important safety information. Benefits outlined on AgelessRx.com are based on 3rd party studies. Medication is offered as a subscription service which you can cancel at any time. Actual product packaging may appear differently than shown. Please allow 3-5 days for processing & shipping following medical approval (if required).

  • 0.5mg strength capsules

  • Slower

  • Ramp up to 4.5mg daily dose or as prescribed

  • 3-month supply

Code LDNQ30: $30 off 1st quarter
($105/Quarter After)
 

Code LDNQ30: $30 off 1st quarter
($35/Month After)

titration process

0.5 Protocol - Quarterly

billed $75 for 1st quarter | free shipping

Get started

First Quarter
$25/mo!

  • 1.5mg strength capsules

  • Standard

  • Ramp up to 4.5mg daily dose or as prescribed

  • 3-month supply

Code LDNQ30: $30 off 1st quarter
($105/Quarter After)
 

Code LDNQ30: $30 off 1st quarter
($35/Month After)

titration process

1.5 Protocol - Quarterly

billed $75 for 1st quarter | free shipping

Get started

Your prescriber may recommend a different dose during your medical intake process.

You can request adjustments to your dosages between refills.

You will be automatically enrolled into our billing/refill program based on your plan.

You can pause or cancel at any time before your next shipment.

Not Sure if LDN is Right For You?

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LDN - Low Dose Naltrexone
Starting at $25/month

LDN ScienceLDN BlogAutoimmune SupportLogin≡ Menu

Low Dose Naltrexone (LDN) modulates your immune system to suppress chronic inflammation and reduce oxidative stress –leading to improved immune function, reduced pain and fatigue, and enhanced quality of life.

FSA / HSA Eligible

LDN - Low Dose Naltrexone
Starting at $25/month

Get started

LDN - Low Dose Naltrexone

Low Dose Naltrexone (LDN) modulates your immune system to suppress chronic inflammation and reduce oxidative stress –leading to improved immune function, reduced pain and fatigue, and enhanced quality of life.

FSA/HSA Eligible 

Get started

Crohn's Disease

In a 2011 study, LDN therapy appears effective and safe in subjects with active Crohn's disease

Rheumatoid Arthritis

RA is most often associated with chronic inflammation, which LDN has been shown to lower chronic inflammation 

Thyroid Dysfunction

LDN has been shown to alleviate some or all symptoms of hypo and hyper-thyroidism, as well as helping to regulate the way the thyroid works

Fibromyalgia

LDN acts on specific pain receptors to reduce their over-sensitivity while stimulating the body to naturally lower inflammation

LDN Use Cases

What AgelessRx customers are saying

The testimonials on this page are from real AgelessRx customers sourced from Trustpilot.com. Individual results may vary. Testimonials are not a guarantee of future results.

Ready to get started?
Start your free online 
visit now. 

Your prescriber may recommend a different dose during your medical intake process.

You can request adjustments to your dosages between refills.

You will be automatically enrolled into our billing/refill program based on your plan.

You can pause or cancel at any time before your next shipment.

First Quarter
$25/mo!

* Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. See below for important safety information. Benefits outlined on AgelessRx.com are based on 3rd party studies. Medication is offered as a subscription service which you can cancel at any time. Actual product packaging may appear differently than shown. Please allow 3-5 days for processing & shipping following medical approval (if required).

You will be automatically enrolled into our billing/refill program based on your plan.

You can request adjustments to your dosages between refills.

Your prescriber may recommend a different dose during your medical intake process.

You can pause or cancel at any time before your next shipment.

Prescription products require an online evaluation with a licensed medical professional who will determine if a prescription is appropriate. See below for important safety information. Benefits outlined on AgelessRx.com are based on 3rd party studies. Medication is offered as a subscription service which you can cancel at any time. Actual product packaging may appear differently than shown. Please allow 3-5 days for processing & shipping following medical approval (if required).

  • 1.5mg strength capsules

  • Standard

  • Ramp up to 4.5mg daily dose or as prescribed

  • 3-month supply

Code LDNQ30: $30 off 1st quarter
($35/Month After)

Code LDNQ30: $30 off 1st quarter
($105/Quarter After)

titration process

1.5 Protocol - Quarterly

billed $75 for 1st quarter | free shipping

Get started
  • 0.5mg strength capsules

  • Slower

  • Ramp up to 4.5mg daily dose or as prescribed

  • 3-month supply

Code LDNQ30: $30 off 1st quarter
($35/Month After)

Code LDNQ30: $30 off 1st quarter
($105/Quarter After)

0.5 Protocol - Quarterly

billed $75 for 1st quarter | free shipping

Get startedtitration process

Slowing aging has never been simpler

  • Promotes cellular energy production.

  • Supports DNA health and repair.

  • Required to “turn off” genes that accelerate degenerative aging processes.

  • NAD+ is a required “helper” molecule for proteins that regulate other cellular functions. 

Explore our treatments

Browse our offerings or tell us about your health goals. 

Pause or cancel anytime

Plus, enjoy ongoing support from our world-class care team.

Get medical review

Fill out a brief intake form and receive a response in 2-3 days.

Enjoy fast, free shipping

Orders are delivered anywhere in the US within 5-7 business days.

Get access to cutting edge longevity treatments without leaving the couch

Slowing aging has never been simpler

  • Promotes cellular energy production.

  • Supports DNA health and repair.

  • Required to “turn off” genes that accelerate degenerative aging processes.

  • NAD+ is a required “helper” molecule for proteins that regulate other cellular functions. 

Explore our treatments

Browse our offerings or tell us about your health goals. 

Pause or cancel anytime

Plus, enjoy ongoing support from our world-class care team.

Get medical review

Fill out a brief intake form and receive a prescriber response in 2-3 days.

Enjoy fast, free shipping

Orders are delivered anywhere in the US within 5-7 business days.

Get access to cutting edge longevity treatments without leaving the couch